Similarly, the two strongest weighted loci in Cluster 2 are ARAP1, a locus at which diabetes risk is thought to be mediated by modulation of STARD10 expression in pancreatic beta cells [62], and SPRY2, a locus at which the closest gene, SPRY2, regulates insulin transcription [63] (S3 Table). The gene discussed is SPRY2; the disease is diabetes mellitus.