Five variants were top weighted (above the threshold of 0.75) in more than one cluster: CDC123/CAMKID (Beta Cell and Proinsulin), HSD17B12 (Beta Cell and Obesity), ADCY5 (Beta Cell and Lipodystrophy), CCND2 (Proinsulin and Lipodystrophy), and HNF4A (Beta Cell and Proinsulin). The gene discussed is ADCY5; the disease is lipodystrophy.