Five variants were top weighted (above the threshold of 0.75) in more than one cluster: CDC123/CAMKID (Beta Cell and Proinsulin), HSD17B12 (Beta Cell and Obesity), ADCY5 (Beta Cell and Lipodystrophy), CCND2 (Proinsulin and Lipodystrophy), and HNF4A (Beta Cell and Proinsulin). This evidence concerns the gene HSD17B12 and obesity due to melanocortin 4 receptor deficiency.