Cluster 4 (Lipodystrophy cluster) appears to represent the same “lipodystrophy-like” insulin resistance cluster previously suggested by Yaghootkar and colleagues [10,64], with all the variants from that previous set that were also associated with T2D being among those loci most strongly weighted in this cluster (PPARG, ANKRD55, ARL15, GRB14, IRS1, and LYPLAL1) (Table 1, S3 Table). This evidence concerns the gene IRS1 and Insulin resistance.