This set of 11 insulin resistance–increasing alleles was felt to represent a “lipodystrophy-like” fat distribution subgroup of insulin resistance variants reminiscent of monogenic lipodystrophy, because they were associated with increased fasting insulin and triglyceride levels but decreased high-density lipoprotein (HDL) cholesterol, adiponectin, and BMI [10]. The gene discussed is ADIPOQ; the disease is lipodystrophy.