We have recently shown that low RANKL mRNA expression in tumor tissue is associated with reduced DFS and bone metastases development,19 but other studies have demonstrated conflicting results.57, 58 In the current study, we found that there is a strong association of high RANK and RANKL mRNA expression with CD3‐positive, CD8‐positive, and FOXP3‐positive lymphocytes, while high OPG mRNA expression was associated only with FOXP3‐positive infiltrating lymphocytes. This evidence concerns the gene TNFRSF11B and neoplasm.