In accordance with a previous report showing a high concurrence of prion disease pathology and AD pathology in Creutzfeldt‐Jacob‐disease (Tousseyn et al., 2015), the histopathology of the present Case 2 possesses strong evidence that Aβ deposition, as well as p‐tau deposition, could be directly or indirectly induced by PrP itself (“secondary degeneration”). The gene discussed is PRNP; the disease is prion disease.