In a previous report of a GSS P102L (GSS102) patient complicated with dementia (Ishizawa et al., 2002), a full‐blown pathology comprised of PrP, p‐tau, and beta‐amyloid (Aβ) was present, and an interesting interaction of PrP, p‐tau, and Aβ was suggested. The gene discussed is PRNP; the disease is dementia.