Supposing PrP deposition were the primary pathology of GSS, p‐tau deposition in GSS could be regarded as a “secondary degeneration” due to PrP deposition, just as p‐tau deposition is likely a “secondary degeneration” due to Aβ deposition in AD (Hardy, Duff, Hardy, Perez‐Tur, & Hutton, 1998). The gene discussed is PRNP; the disease is Alzheimer disease.