Furthermore, post-mortem analyses of C9ALS/FTD patients who died early (but of other causes), revealed only abundant DPR pathology, further indicating DPR pathology precedes that of TDP-43 (Proudfoot et al., 2014; Baborie et al., 2015; Vatsavayai et al., 2016). This evidence concerns the gene TARDBP and frontotemporal dementia.