Moreover, in C9ALS/FTD tissue sections, poly-GA, poly-GP and poly-GR inclusions were detectable that overlapped with KPNA4 pathology (Fig. 6B, arrows), but as was the case for phospho-TDP-43 labelled inclusions, nuclear depletion of KPNA4 was frequently observed in cells devoid of sense DPR inclusions (Supplementary Fig. 10, arrows). This evidence concerns the gene KPNA4 and frontotemporal dementia.