Similarly, mutations in PIEZO2, which encodes a mechanosensitive ion channel responsible for mechanosensation of light touch and proprioception, can cause a neuromuscular disease characterized by muscle atrophy, mild sensory involvement, delayed motor milestones and scoliosis (Chesler et al., 2016; Delle Vedove et al., 2016); suggesting that defects within sensory neurons themselves can lead to muscle defects and delayed motor development. Here, PIEZO2 is linked to neuromuscular disease.