The current results are consistent with previous studies on presumed preclinical Alzheimer’s disease, reporting decreased fibre tract integrity within the posterior parietal white matter and medial temporal white matter to be associated with imminent conversion from asymptomatic cognitive status to mild cognitive impairment within 2 years (Zhuang et al., 2012) or with the presence of both abnormal levels of CSF amyloid and neuroinjury markers (FDG-PET hypometabolism or CSF tau) (Bendlin et al., 2012; Kantarci et al., 2014). Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.