Based on studies of angiotensin II-induced hypertension (19, 29, 56) and spontaneously hypertensive rats (SHRs) (67, 70) indicating sex differences in T cell activation in hypertension, where hypertensive male animals exhibit a more proinflammatory T cell profile compared with female animals, the present study was designed to test the hypothesis that male DSS rats will have greater increases in BP and T cell infiltration in the vasculature and kidney in response to a HFD compared with female DSS rats. This evidence concerns the gene AGT and hypertensive disorder.