The dysregulation of MAPK is implicated in various human diseases, such as cancer and immune diseases.19 There are reports that some drugs inhibiting laryngeal cancer are acting through the MAPK pathway.6, 13 In our study, we examined the expression of three subfamilies of related proteins, ERK, JNK, and p38, in response to irradiation and Tanshinone IIA treatment. The gene discussed is MAPK8; the disease is immune system disorder.