IGHE and allergic disease: Possible vaccine‐induced allergic reactions can be mitigated when selecting vaccine antigens by in silico screening out of potentially allergenic antigens using bioinformatics tools, such as the Structural Database of Allergenic Proteins (SDAP), that predict antigens that IgE binds.79 This was, in fact, performed for the schistosomula antigens used in this study, by TheSchistoVac (http://www.theschistovac.eu/).