In a previous study we reported that inhibition of peripheral FAAH, with the consequent increase in peripheral levels of AEA, reduces hyperalgesia as well as c-Fos expression in the nucleus trigeminalis caudalis (NTC) and the locus coeruleus in a well-known animal model of migraine based on nitroglycerin (NTG) administration. The gene discussed is FOS; the disease is migraine disorder.