Plasma levels of biomarkers of inflammation: interleukin 6 (IL-6), interleukin 10 (IL-10), high-sensitivity C-reactive protein (hs-CRP), calcitonin gene-related peptide (CGRP); endothelial dysfunction: pentraxin 3 (PTX3), soluble TNF-like weak inducer of apoptosis (sTWEAK); blood-brain barrier disruption: cellular fibronectin. This evidence concerns the gene IL6 and endothelial dysfunction.