PROS1 and hyperinsulinemic hypoglycemia, familial, 4: We also found that in migraine patients, aPLs positivity was independently associated with both IS or TIA (OR=5.6, 95% CI 1.5-20.4, p=0.009) and coronary heart disease (OR=27.6, 95% CI 1.4-531.1, p=0.028) whereas free protein S deficiency was associated with IS or TIA only (OR=14.3, 95% CI 2.8-74.4, p=0.002).