Our study indicates that migraine is comorbid with free protein S deficiency and aPLs positivity and that those factors are associated with the occurrence of vascular events in migraine patients, suggesting that in migraine-prone subjects, comorbid thrombophilic defects may favor migraine attacks occurrence and concur to ischemic events. This evidence concerns the gene PROS1 and hyperinsulinemic hypoglycemia, familial, 4.