Studies have shown TRAIL to be critical among tumor necrosis factor (TNF) family members in the NK cell‐mediated antitumor function.20, 43 Moreover, CRC cells are susceptible to TRAIL‐induced apoptosis, both as a single agent of recombinant TRAIL and combined with chemotherapy and targeted therapies.44 Thus, giving preoperative chemotherapeutic agents phenotypically activated liver NK cells; however, the underlying mechanism remains unclear. This evidence concerns the gene TNFSF10 and colorectal carcinoma.