KLRK1 and neoplasm: In addition, NKG2D ligand expression is reportedly correlated with better clinical prognosis in CRC.46 In this study, neoadjuvant chemotherapy did not affect the expression of non‐classical MHC class I antigens on CRLM tumor tissues, suggesting that chemotherapeutic agents might not diminish susceptibility to NK cell‐mediated anti‐tumor cytotoxicity.