Treg cells inhibit both monocyte and neutrophil function,38 and induce an NK cell‐dependent endotoxin tolerance‐like phenomenon that is characterized by the decreased production of IFN‐γ.39 There is a large amount of evidence that patients with sepsis have increased numbers of Treg cells, which, by acting both on innate and adaptive immune cells, impair immunity and contribute to septic mortality. The gene discussed is IFNG; the disease is Sepsis.