Recent studies showed that disruption of the PD‐1/PD‐L1 axis either by genetic deletion or by pharmacological manipulation improves survival in bacterial and fungal murine sepsis.46, 47 Boomer et al showed that PD‐1 expression was increased in CD4 and CD8 T cells, whereas PD‐L1 expression was increased in antigen‐presenting cells as well as in the spleen and lungs of septic patients. Here, CD274 is linked to Sepsis.