We recently showed that the IFN‐γ‐producing capacity of human peripheral blood mononuclear cells (PBMC) is severely impaired in both postoperative patients after elective surgery and in septic patients.28 Impaired IFN‐γ production in response to lipopolysaccharide (LPS) has been reported in NK cells from patients with sepsis. The gene discussed is IFNG; the disease is Sepsis.