On the other hand, a recent study found that the dual GR/progesterone antagonist mifepristone and the GR-specific antagonist CORT113176 each dose-dependently reduced escalated alcohol intake in rats and, in a companion clinical study, maintenance on mifepristone 600 mg/day (vs. placebo) reduced alcohol drinking among individuals with alcohol use disorder (Vendruscolo et al., 2015). The gene discussed is NR3C1; the disease is alcohol abuse.