Protein alterations such as serum polyclonal α- β- and γ-hyperglobulinemia, hyperproteinemia, hypoalbuminemia and decreased albumin/globulin (A/G) ratio have been associated with disease progression (Ciaramella et al., 1997; Koutinas et al., 1999; Giunchetti et al., 2008b; Meléndez-Lazo et al., 2018). This evidence concerns the gene ALB and Hypoalbuminemia.