OGT can induce the differentiation of MDS/AML cells in vitro and extend the survival rate of mice carrying leukemic cells expressing mutant ASXL1, which occurs at high frequencies in myeloid malignancies, by conjugating O-GlcNAc to ASXL1-S199 and thereby stabilizing this tumor suppressor protein (67). This evidence concerns the gene ASXL1 and acute myeloid leukemia.