Regulation of EET levels using sEH inhibitors, which hydrolyze EETs in the brain, has been explored as therapy for cerebral vascular diseases, such as stroke, because EETs will improve cerebral blood flow as vasodilators.14 Therefore, the increase in EET levels by suppression of sEH activity in neuronal cells may also be effective in enhancing neurogenesis. The gene discussed is EPHX2; the disease is stroke disorder.