MYCN-specific siRNA was not used, because mouse neuroblastoma cells express low basal levels of MYCN.Neuroblastoma cells were transfected for 72 h with negative control siRNA, siRNA-HADC8, siRNA-c-MYC, or siRNA-HDAC8 + siRNA-c-MYC (Figure 7A). The gene discussed is MYC; the disease is neuroblastoma.