The effects resemble, but are not as dramatic as, those enacted by pharmacologic inhibition of LSD1 (a non-Jumonji histone demethylase with dual specificity for H3K4me2/3 and H3K9me1/2) in Ewing Sarcoma, which showed near-complete opposition of both EWS/Fli1-upregulated and downregulated transcriptomes [15]. This evidence concerns the gene EWSR1 and Ewing sarcoma.