Recent in vitro results from our group (in preparation) indicates that this biomaterial reduces the secretion of BDNF, SDF1-Alpha and VEGF from mSCs, while substantially augments (up to 10 times more) the secretion of TGF-Beta1, a known anti-inflammatory and angiogenic factor that is strongly induced after brain injury polarizing microglia to an anti-inflammatory phenotype (Rustenhoven et al., 2016) increasing functional recovery after acute brain injury (Taylor et al., 2017). This evidence concerns the gene TGFB1 and brain injury.