TP53 and cancer: A lot of research has been done in which the p53–MDM2 interaction has been successfully disrupted.4 Another extensively studied ubiquitous protein that has been shown to negatively regulate wt p53 is called E6 oncoprotein in cervical cancers since it possesses the E3 ligase activity, an important function that is needed during cancer development.5 RBBP6 is yet another suspected deregulator of wt p53 due to its E3 ligase activity as well as the presence of p53, DWNN and RING finger-like domains.6 However, the underlying mechanism in which RBBP6 negatively regulates wt p53 is currently unclear.