ADAT3 and intellectual disability, autosomal recessive: For example, although only one single missense variant in ADAT3 has been reported, it has emerged as the single most common cause of nonsyndromic autosomal recessive intellectual disability in Arabia such that there is now little doubt about the disease–gene link.32–35 It is for this reason that we opted to include in this study, as another confirmatory method, cases with similar variants to those previously reported if they corroborate the positional mapping evidence even as we acknowledge the possibility of being in linkage disequilibrium with the actual causal variants.