NOTCH1 and liver dysplastic nodule: Furthermore, whether the levels of apoptosis and autophagy in the glomerulus could be regulated by activated Notch-1 signaling was measured in this study, and the significance of microenvironment in vivo and balance between apoptosis and autophagy were also discussed in conditions associated with DN, which may provide a basis for the development of targeted treatments and assessment of individuals in clinical islet transplantations in various diabetic patients.