NGB and Stroke: As our lab and others have extensively documented that Ngb confers neuroprotection against stroke through ROS scavenging, improving mitochondrial function and suppressing apoptosis2,47, the findings in this current study will broaden our understanding of Ngb functions in stroke pathogenesis, and suggest that the enhanced neurogenesis may be an additional mechanism contributing to the improved neurological outcomes after stroke by Ngb overexpression9.