In addition, SIRT1 deacetylates YAP2 protein in HCC cells and SIRT1-mediated deacetylation increases the YAP2/TEAD4 association, leading to YAP2/TEAD4 transcriptional activation and upregulated cell growth and enhances the chemosensitivity of HCC cells36,37. This evidence concerns the gene SIRT1 and hepatocellular carcinoma.