To further investigate whether the promoting effect of RIF1 on cell growth and CSC-like properties in NSCLC was correlated with β-catenin activation, we also examined the effect of blocking Wnt/β-catenin signaling would have on cell growth and the CSC-like traits of RIF1-overexpressed NSCLC cells. Here, RIF1 is linked to non-small cell lung carcinoma.