Among them, NCOA3/SRC3 is a co-activator for androgen receptor (AR) and promotes PCa tumorigenesis [7, 19]; DEK acts as a proto-oncogene involved in mRNA processing and DNA replication [11]; ERG is one member of ETS family of transcription factor, and considered as one marker for prostate cancer [10]. This evidence concerns the gene NCOA3 and Familial prostate cancer.