In summary, the data suggest that BI 853520 is more potent in repressing tumor cell proliferation and primary tumor growth of differentiated, E-cadherin-expressing tumor cells (MTflECad, Py2T, in parts 4T1 cells and early stages of MMTV-PyMT tumor progression), while it represses the metastatic outgrowth of invasive, E-cadherin-deficient tumor cells (MTΔECad and late stages/metastasis of MMTV-PyMT tumor cells). Here, CDH1 is linked to neoplasm.