CDH1 and breast cancer: On the other hand, BI 853520 most effectively hampers the establishment of pulmonary metastasis in mice harboring E-cadherin-deficient (MTΔECad) tumors (Fig. 6c), the metastatic outgrowth of 4T1 breast cancer cells with downregulated E-cadherin expression (Fig. 2a), and the 3D Matrigel invasion of mesenchymal Py2T-LT cells (Fig. 1f and Suppl.