Subsequently, phosphorylated Y397 serves as a docking site for SRC homology 2 containing SRC family kinases, which results in a fully active FAK-SRC signaling complex that can trigger various downstream signaling pathways known to control cell migration, invasion, proliferation, and death—all activities pivotal for malignant tumor progression3,7,10,11,14–18. The gene discussed is PTK2; the disease is cancer.