In agree with this notion, we screen the differentially expressed genes among miR-125b antagomir-, control-, and miR-125b agomir-transfected tumor cells without bias; then, the gene lists are further filtered using several miRNA target prediction algorithms; and finally, CSF1 and CX3CL1 are confirmed to be direct targets of miR-125b by luciferase assays in this study. This evidence concerns the gene CSF1 and neoplasm.