Further, as previously reported, we noted that p-ERK rebound was sensitive to MEK inhibition19, i.e although recovery of p-ERK was detectable at 24 h in the combination BRAF/MEK inhibitor treated parental melanoma cells, rebound was less pronounced in the presence of the MEK inhibitor trametinib (Figure S2B, C). The gene discussed is MAP2K7; the disease is melanoma.