The macrophages treated with conditioned medium (CM) from LNMAT1-transduced bladder cancer cells, but not with CM from the control group, displayed a stretched and elongated morphology and exhibited a CD206 high /HLA-DR low phenotype (Fig. 7c and Supplementary Fig. 10c), indicating functional activation of the macrophages. This evidence concerns the gene MRC1 and urinary bladder cancer.