INS and metabolic dysfunction-associated steatohepatitis: In consequence, the progression from healthy liver to non-alcoholic steatohepatitis is accompanied by enhanced 5-LO product levels48, and deletion of 5-LO has (i) anti-steatotic, anti-inflammatory, and anti-fibrotic effects in experimental models of liver disease49, (ii) protects from hepatic inflammatory injury, and (iii) improves insulin signaling at high-fat diet14.