After adjustment for age; sex; status of liver cirrhosis and serum levels of ALT, AST, AFP and HCV RNA, the HR for HCC was 4.36 (95% CI: 2.61–7.29; p < 0.001) for the participants with increasing WFA+-M2BP levels equal to or higher than 0.3 COI compared with that for the participants with increasing WFA+-M2BP levels less than 0.3 COI. The gene discussed is AFP; the disease is hepatocellular carcinoma.