In this study, we show that liver fibrosis progression is associated with the repression of GNMT, which is targeted by miR-873-5p in two preclinical models of liver fibrosis and cholestasis: the bile duct ligation (BDL) and the Mdr2 (Abcb4)-deficient mice (Mdr2-/-), respectively. Here, ABCB4 is linked to cholestasis.