Moreover, miR-873-5p inhibition increased the expression of different genes related to BA-induced apoptosis [B-Cell CLL/Lymphoma 2 (Bcl2) and the Hepatocyte nuclear factor (Hnf) Hnf1α and Hnf4α] and, more importantly, genes implicated in BA metabolism and regulation, such as the master regulator of BA metabolism Fxr and different BA exporters, such as Bsep, Abcg5 and some Mdr/Mrp (Fig. 4e). The gene discussed is NR1H4; the disease is B-cell chronic lymphocytic leukemia.