In vitro tests revealed that decreasing Rab3A in Huh7, SK-hep1, and HCCLM3 cells conferred no significant effects on migration and invasion, whereas overexpressing Rab3A in Hep3B and PLC/PRF/5 cells significantly inhibited migration and invasion (Fig. 2c–d), indicating that Rab3A is capable to inhibit HCC migration and invasion in Hep3B and PLC/PRF/5 cells, and there might be some regulatory factors suppressing the functions of Rab3A in other tumor cell lines. The gene discussed is HSPG2; the disease is neoplasm.