However, no phosphorylation was detected on Rab3A, and despite the synchronous level changes of Rab3A and its O-GlcNAcylation in different HCC cells, OGT knockdown failed to downregulate Rab3A levels (Fig. 3a–b), suggesting that O-GlcNAcylation might not regulate the potential signaling or the stability of Rab3A in HCC. The gene discussed is OGT; the disease is hepatocellular carcinoma.