EGFR and gastric cancer: Conversely, the antiapoptotic effects triggered by overexpression of NOX4 were blocked by the depletion of ROS (Supplementary Fig. 3B), which was accompanied by the downregulation of EGFR as well as the inhibition of aggregation of plasmid-NOX4-transfected GC cells (Supplementary Fig. 3A, C and D).