CCN6 and chondrosarcoma: Pretreating chondrosarcoma cells with PI3K inhibitors (Ly294002, wortmannin) or siRNAs abolished CCN6-mediated cell migration, invasion, and MMP-9 mRNA expression (Fig. 2a–f), while transfection of cells with p85 or Akt siRNAs inhibited p85 and Akt expression (Fig. 2g).