DNM1L and hepatocellular carcinoma: Consistently, a previous study in HCC has shown that increased mitochondrial fragmentation by overexpression of DRP1 or knockdown of MFN1 promoted the growth of HCC cells both in vitro and in vivo, whereas enhanced mitochondrial network by knockdown of dynamin-related protein 1 (DRP1) or overexpression of mitofusin-1 (MFN1) exhibited an opposite effect12.