Interestingly, knockout mice of Podxl and calreticulin (Calr), genes which are involved in the regulation of EMT in cultured cell lines (Meng et al., 2011; Hayashida et al., 2006), show middle-type omphalocele (Doyonnas et al., 2001; Mesaeli et al., 1999; Rauch et al., 2000). This evidence concerns the gene PODXL and omphalocele.