This suggests that elevated gene expression of GSK-3β is associated with low expression of PI3K / Akt signaling protein, and high glucose inhibits the activation of PI3K/Akt signaling pathway in cardiomyopathy, reduced the phosphorylation of GSK-3β, up-regulated the expression of GSK-3β and ultimately induced cardiomyocyte apoptosis. The gene discussed is AKT1; the disease is cardiomyopathy.