Recently, the existing classic theranostic concept comprising diagnostic imaging and targeted radionuclide therapy has been expanded by the use of 111In-PSMA-I&T (19) and 99mTc-PSMA-I&S (for imaging and surgery) (20) for PSMA-targeted radioguided surgery of soft-tissue metastases in oligometastatic recurrent prostate cancer (21–23). This evidence concerns the gene FOLH1 and Familial prostate cancer.