For example, Echinoderm Microtubule-associated protein-Like 4-Anaplastic Lymphoma Kinase (EML4-ALK) fusion gene is present in 4–5% of NSCLC cases and generates EML4-ALK fusion protein to activate ALK-associated oncogenic signaling and promote NSCLC progression [3–5]. The gene discussed is EML4; the disease is non-small cell lung carcinoma.