Overall, the histopathological analysis revealed great heterogeneity of cherubism granulomas, in part due to the aggressiveness of the disease; and the unexpected and atypical expression of the RANK/RANKL/OPG triad in cherubism granulomas (low expression of RANKL by cells outside the MGC area; high expression of OPG around the MGC; variable expression of RANK by both MGC and stromal cells) (Table 2). Here, TNFRSF11B is linked to cherubism.