As cherubism was recently described as being an auto-inflammatory bone disease, we focused on the expression of genes involved in osteoclastogenesis (RANK, RANKL, M-CSF, OPG, NFATc1), bone formation (ALP, Osteocalcin), and inflammation (IL6, IL6R, TNFα, TNFR1, TNFR2, IL17) (Additional file 5). The gene discussed is IL6R; the disease is cherubism.