Among them, MUC16 and MUC20 membrane-bound mucins and their combination MUC4/MUC16/MUC20 is associated with a poorer overall survival in different cancers including pancreatic, colon and stomach cancers suggesting MUC4/MUC16/MUC20 as a poor prognostic signature for these cancers. The gene discussed is MUC4; the disease is gastric cancer.