In agreement with the findings of WG-DASL gene expression profiling, qPCR confirmed significant upregulation of THBS2, CSPG2, MMP11, GREM1 and COL10A1 and downregulation of KRT14 in IBC compared to the corresponding DCIS (Fig. 3a). This evidence concerns the gene KRT14 and ductal breast carcinoma in situ.