However, these candidate genes, especially MMP11 and COL11A1, were all detected in microdissected DCIS (of DCIS/IBC mixed tumors) and in pDCIS where we could safely and completely isolate tumor cells from the surrounding stroma, therefore proving the expression of these genes in neoplastic epithelial cells. The gene discussed is MMP11; the disease is ductal breast carcinoma in situ.