High levels of log plasma adiponectin (OR, 1.66; 95% CI, 1.08–2.55) and leptin (OR, 2.00; 95% CI 2.00; P-value = 0.022); 95% CI, 1.18–3.38; P-value = 0.009) were significantly associated with incident CKD. Here, LEP is linked to chronic kidney disease.