To explore better treatment options for ischemic stroke and reperfusion injury, researchers have carried out extensive studies on its pathogenesis; proposed a set of theories [4,5] mainly including energy metabolism disorders, oxidative stress, glutamate toxicity, Ca2+ overload, excessive NO synthesis, and apoptosis; and developing a series of new drugs [5], such as recombinant tissue plasminogen activator (r-TPA), aspirin and heparin. Here, PLAT is linked to ischemic stroke.