Many investigators, including us, have shown that chalcones exert anticancer activity against different cancer cell lines through mechanisms such as cell cycle disruption, the inhibition of angiogenesis, tubulin polymerization, the induction of apoptosis, the blockade of the NF-κB signaling pathway, and the induction of p53 protein [17,18,35]. Here, NFKB1 is linked to cancer.