OPG mRNA was decreased, RANKL mRNA was upregulated, and the ratio of OPG/RANKL mRNA was decreased in the OVX/T1DM group compared with the control group (p < 0.01), which were totally recovered by salidroside treatment for 60 days (OVX/T1DM-SAL group). The gene discussed is TNFRSF11B; the disease is type 1 diabetes mellitus.