Serum alkaline phosphatase (ALP), c-terminal telopeptide of type 1 collagen (CTX-1), osteocalcin, tartrate-resistant acid phosphatase 5b (TRACP 5b), N-terminal propeptide of type I procollagen (PIPN), and RANKL were significantly higher in the OVX/T1DM group than those in the OVX/T1DM-SAL and control groups (p < 0.01). The gene discussed is TNFSF11; the disease is type 1 diabetes mellitus.