The serum OPG/RANKL ratio, bone OPG/RANKL mRNA expression ratio, and bone OPG/RANKL protein expression ratio were all increased in the OVX/T1DM-SAL group compared with the OVX/T1DM group, and there were no differences of those indexes between OVX/T1DM-SAL and control groups. This evidence concerns the gene TNFSF11 and type 1 diabetes mellitus.