However, proprotein convertase subtilisin/kexin type 9 (PCSK9), which is overexpressed in patients with familial hypercholesterolemia, competitively binds to the LDLR and inhibits the rearrangement of the LDLRs recycled to the plasma membrane, leading to high levels of LDL-C in the plasma [5,6]. The gene discussed is LDLR; the disease is familial hypercholesterolemia.