In that study, by using a genetic mouse model expressing in the liver a gain-of-function AMPKγ1 mutant, Woods et al. demonstrated that the effect of hepatic AMPK activation in the protection against hepatic steatosis is largely dependent on the suppression of de novo lipogenesis, but not on the stimulation of hepatic fatty acid oxidation [10]. This evidence concerns the gene PRKAA2 and Hepatic steatosis.